What is the molecular mass range of drugs commonly referenced?

The typical molecular mass range of drugs that are commonly referenced falls between 100 and 500 daltons (or atomic mass units, denoted as 'u'). This range is significant because most drug-like molecules are designed to have suitable pharmacokinetic and pharmacodynamic properties, which are often optimal within this molecular weight range.

Compounds within 100 to 500u tend to have the proper balance of lipophilicity and hydrophilicity, allowing them to adequately penetrate biological membranes while remaining soluble in physiological fluids. Molecules at this weight can interact effectively with biological targets (like enzymes or receptors) and have a higher likelihood of being absorbed and distributed throughout the body.

Drugs that are significantly smaller than this range (e.g., less than 100u) might lack the structural complexity necessary to interact with biological targets effectively. On the other hand, drugs that exceed the upper limit (over 500u) might face difficulties with absorption and distribution due to their increased size and reduced ability to permeate cell membranes. Additionally, larger molecules can have challenges with stability and may be recognized as foreign by the immune system.

Therefore, the range of 100 to 500u is optimal for developing compounds that can serve as effective therapeutics in